One of the biggest concerns for safari travelers is the risk of malaria. The good news? South Africa boasts a selection of malaria-free game reserves, allowing you to experience the magic of the African wilderness without worry. If you’re wondering where to go on a malaria-free safari, this guide highlights the top destinations, wildlife, activities, best times to visit, and luxury lodges.
Whether you’re a family traveling with young children, an expecting parent, or simply prefer a malaria-free safari experience, these destinations provides our guests with peace of mind.
What are Malaria-Free Game Reserves?
Malaria-free game reserves are protected wildlife areas where the risk of contracting malaria is entirely eliminated. As a result, these reserves provide safe and enriching safari experiences, ensuring you can explore Africa’s breathtaking landscapes and incredible wildlife without hesitation or the need for anti-malaria medication.
At Marula Hill Travel, many of our guests opting for malaria-free reserves include pregnant moms, families with young children, and multi-generational travelers. Additionally, these destinations offer Big Five encounters, diverse ecosystems, and luxury accommodations—all while ensuring a completely malaria-free environment. Therefore, you can enjoy an unforgettable safari with complete peace of mind.

Where to Go on a Malaria-Free Safari: Top Game Reserves in South Africa
1. Madikwe Game Reserve – North West Province
One of South Africa’s largest and most prestigious reserves, Madikwe Game Reserve spans 75,000 hectares and is renowned for its Big Five sightings—lions, leopards, rhinoceros, elephants, and buffalo. It is also a leader in conservation, having successfully reintroduced over 20 wildlife species. The diverse landscapes, ranging from rocky outcrops to open grasslands, create an unforgettable setting for game drives. Bird enthusiasts will find over 300 species to observe, making it an excellent choice for nature lovers.
Top Lodges in Madikwe:
- Madikwe Safari Lodge
- Morukuru Farm House
- Jamala Madikwe
2. Eastern Cape Game Reserves
The Eastern Cape is home to some of South Africa’s most celebrated malaria-free reserves, offering exceptional wildlife viewing and strong conservation initiatives. Shamwari Game Reserve stands out for its commitment to wildlife rehabilitation and luxurious safari lodges. Addo Elephant National Park is renowned for its large elephant herds, while Pumba Private Game Reserve is known for its rare white lions. Each reserve offers a distinct experience, from open savannah game drives to lush forest landscapes for a malaria-free safari.
Top Lodges in the Eastern Cape:
- Shamwari Sindile
- Shamwari Eagles Crag
3. Waterberg Biosphere – Limpopo
The Waterberg region undoubtedly offers a secluded and intimate safari experience, set against dramatic mountains, winding rivers, and expansive savannahs. Moreover, as a UNESCO Biosphere Reserve, this area remains a hidden gem for those seeking both exclusivity and meaningful rhino conservation efforts.
Specifically, Welgevonden Game Reserve stands out for its commitment to non-commercial tourism, thereby ensuring a private and immersive safari experience. In addition, visitors can revel in breathtaking landscapes, thrilling wildlife encounters, and most importantly, some of the most luxurious lodges in South Africa. As a result, the Waterberg region provides a perfect blend of adventure, conservation, and indulgence.
Top Lodges in Waterberg:
- Marataba Safari Lodge
- Mhondoro Safari Lodge
- Tshwene Lodge
The Welgevonden Game reserve is close to Johannesburg. From more information about reserves close to Johannesburg, please read our blog: Discover the Best Malaria-Free Safaris Near Johannesburg

4. Western Cape Game Reserves
For those wanting a malaria-free safari near Cape Town, the Western Cape offers Big Five game viewing within spectacular landscapes featuring both savannah and fynbos vegetation. Gondwana Game Reserve and Sanbona Wildlife Reserve offer unique ecosystems and conservation programs. Guests can embark on game drives, guided bush walks, and cultural experiences while enjoying world-class hospitality. Sanbona Wildlife Reserve is particularly known for its white lion conservation efforts and its luxury tented accommodation.
Top Lodge in the Western Cape:
- Sanbona Dwyka Tented Lodge
Each of these malaria-free reserves offers a combination of luxury, conservation, and exclusive wildlife encounters, making them perfect for families, couples, and first-time safari-goers looking for a worry-free African adventure.
Activities & Wildlife in Malaria-Free Game Reserves
A malaria-free safari doesn’t mean compromising on adventure. These reserves offer a variety of experiences, including game drives, guided bush walks, and night safaris. Wildlife sightings include the Big Five, as well as cheetahs, hippos, and antelope species. Birdwatching is exceptional in these areas, with vibrant species thriving in diverse ecosystems. Some reserves also offer stargazing, cultural visits, and conservation experiences, adding depth to your safari experience.
For those seeking a more immersive adventure, guided walking safaris provide an opportunity to track wildlife on foot, learning about their behavior and habitat from expert guides. Many reserves also focus on conservation and community involvement, allowing visitors to participate in educational programs and support local initiatives.
Best Time to Visit Malaria-Free Game Reserves
The best time to visit malaria-free game reserves depends on your preferences. The dry season, from May to September, offers the best game viewing as wildlife gathers around water sources, making sightings more predictable. The sparse vegetation also allows for better visibility of animals, making it an excellent time for photographers and first-time safari-goers.
Spring and autumn, from September to November and March to May, bring lush landscapes, newborn animals, and moderate temperatures. These seasons provide an excellent balance between good game viewing and scenic beauty, making them ideal for travelers who enjoy vibrant landscapes and a mix of wildlife activity.
Cape Town is a city that does not have malaria, so is safe to travel. Please read our blog: Safari In Cape Town. Is it Worth Doing?
Final Thoughts
If you’ve been wondering where to go on a malaria-free safari, South Africa offers exceptional destinations that provide world-class game viewing without the health risks. Whether you seek the Big Five, luxury lodges, or diverse landscapes, these reserves offer everything you need for an unforgettable adventure.
For a seamless start to planning your malaria-free safari, connect with Marula Hill Travel, an award-winning safari travel planning agency. Moreover, we’re here to guide you through every step, ensuring a stress-free experience from start to finish. Best of all, we offer a complimentary consultation, so you can explore your options with expert advice at no cost. Get in touch today, and let’s start crafting your unforgettable safari adventure!
📧 Email: sian@marulahill.com
📞 Call / WhatsApp: +27 82 459 0648
📸 Instagram: @marula_hill_travel
🌍 Website: www.marulahill.com
Your dream malaria-free safari begins today!